November 5, 2015 9:31am

Infusion of Cellectis’s UCART19 T-cells helped induce molecular remission in 11-month-old with acute lymphoblastic leukemia after all other treatments failed, according to investigator-sponsored data being presented at American Society of Hematology annual meeting.


 

Patient received single dose without significant toxicity

UCART19 T cells were detectable by qPCR in circulation by day 14, and at increased levels in both blood and marrow on day 28

 

The Boittom Line: Patient showed signs of count recovery and bone marrow, while hypoplastic, was in cytogenetic and molecular remission.   U.K. researchers said first-in-human use provides early proof-of-concept for off-the-shelf CAR T-cell approach

 

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< Source: Bloomberg by Catherine Larkin and Caroline Chen>